These findings support the hypothesis that olfactory bulbectomy induces a behavioral hypersensitivity to estrogen, and suggest that sexual motivation is an estrogen-mediated response which requires a higher level of estrogen stimulation than sexual receptivity and proceptivity. In contrast, sexual motivation was only demonstrated by olfactory bulbectomized females which received 100% E2 in combination with 500 μg P. Results showed that olfactory bulb removal facilitates sexual receptivity and proceptivity in females exposed to 10% or 100% E2 in combination with 500 μg P. Two recent reports suggest abnormalities of the. In women with prenatal androgen excess, heterosexuality appears to be more frequent than bisexuality, and exclusive homosexuality is rare. Sexual receptivity (lordosis) was measured separately in a glass arena with a sexually active male. Sex hormone levels were found to be normal in the majority of homosexual women, but about a third of the subjects studied had elevated androgen levels. Sexual motivation (as indicated by a female's preference for a sexually active male over a castrated male) and proceptivity (dart and ear wiggling sequences) were measured in a three compartment partner preference apparatus. Females received one of four subthreshold hormone treatments: 0% estradiol (E2) plus 500 μg progesterone (P), 100% E2 alone, 10% E2 plus 500 μg P, or 100% E2 plus 500 μg P. Ovariectomized female rats underwent either bilateral bulbectomy or sham surgery. The purpose of the present experiment was to assess the effect of olfactory bulbectomy and ovarian hormones on female sexual motivation.
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